Clinical Guide to Probiotic Products Available in USA
Applications, Dosage Forms and Clinical Evidence to Date -
2024 Edition
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Application (select all that apply with ctrl+click)
AAD - Antibiotic associated diarrhea - Prevention
C - Constipation
CDAD - Clostridium difficile associated diarrhea - Prevention
CE/AD - Childhood eczema/ Atopic dermatitis
CID - Common infectious disease - community acquired
CMPA - Cow Milk Protein Allergy (including Colic due to CMPA)
Colic - Colic
HP - Helicobacter pylori - Adjunct to standard eradication therapy
IBD-UC - IBD - Ulcerative colitis - Adjunct to standard therapy
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
ID - Infectious diarrhea
LH - Liver Health (NASH/NAFLD/MHE; as adjunct to standard therapy; see studies for specific population)
NEC* - Necrotizing Enterocolitis (newborn) *as per hospital protocol, not for self-administration
NI - Nosocomial infections prevention - hospital acquired
OH - Oral health (reductions of tonsillitis, laryngitis, and dental caries)
Regurg/ GI Mot - Reduces regurgitation/ Improves gastrointestinal motility
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PROBIOTIC APPLICATIONS IN PEDIATRIC HEALTH
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Brand Name
Probiotic Strain
Applications (Level of Recommendation)
Dosage Form
CFU/Dose
No of Doses/Day
Bio-Kult® Infantis
🌾
L. casei PXN® 37™
L. rhamnosus PXN® 54™
Streptococcus thermophilus PXN® 66™
L. acidophilus PXN® 35™
B. breve PXN® 25™
L. delbrueckii ssp. bulgaricus PXN® 39™
B. infantis PXN® 27™
CE/AD - Childhood eczema/ Atopic dermatitis (II)
Colic - Colic (II)
HP - Helicobacter pylori - Adjunct to standard eradication therapy (II)
Sachet
1B/sachet
½ -1 sachet
BioGaia® Prodentis® KIDS
L. reuteri ATCC PTA 5289
L. reuteri DSM 17938
OH - Oral health (reductions of tonsillitis, laryngitis, and dental caries)
(I)
Lozenge
200M/lozenge
1 lozenge
BioGaia® Protectis® Baby Drops
L. reuteri DSM 17938
AAD - Antibiotic associated diarrhea - Prevention
(I)
C - Constipation
(I)
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired
(I)
Colic - Colic
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
NEC* - Necrotizing Enterocolitis (newborn) *as per hospital protocol, not for self-administration
(I)
Regurg/ GI Mot - Reduces regurgitation/ Improves gastrointestinal motility
(I)
Drops
100M/5drops
5 drops
BioGaia® Protectis® Baby Drops with Vitamin D
L. reuteri DSM 17938
AAD - Antibiotic associated diarrhea - Prevention
(I)
C - Constipation
(I)
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired
(I)
Colic - Colic
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
Regurg/ GI Mot - Reduces regurgitation/ Improves gastrointestinal motility
(I)
Drops
100M/5drops
5 drops
BioGaia® Protectis® Chewable Tablets
L. reuteri DSM 17938
AAD - Antibiotic associated diarrhea - Prevention
(I)
C - Constipation
(I)
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired
(I)
Colic - Colic
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
Regurg/ GI Mot - Reduces regurgitation/ Improves gastrointestinal motility
(I)
Chewable tablet
100M/tablet
1 tablet
Chewable FloraVantage® Probiotic
🌾
L. acidophilus NCFM®
B. animalis subsp lactis Bi-07®
CID - Common infectious disease - community acquired
(I)
Chewable tablet
5B/tablet
2 tablets
Culturelle® Immune Defense
🌾
L. rhamnosus GG
AAD - Antibiotic associated diarrhea - Prevention
(I)
CE/AD - Childhood eczema/ Atopic dermatitis
(I)
CID - Common infectious disease - community acquired
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
LH - Liver Health (NASH/NAFLD/MHE; as adjunct to standard therapy; see studies for specific population) (II)
NI - Nosocomial infections prevention - hospital acquired
(I)
Chewable tablet
5B/tablet
1-2 tablets
Culturelle® Kids Purely Probiotics Chewables
L. rhamnosus GG
AAD - Antibiotic associated diarrhea - Prevention
(I)
CE/AD - Childhood eczema/ Atopic dermatitis
(I)
CID - Common infectious disease - community acquired
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
LH - Liver Health (NASH/NAFLD/MHE; as adjunct to standard therapy; see studies for specific population) (II)
NI - Nosocomial infections prevention - hospital acquired
(I)
Chewable tablet
5B/tablet
1-2 tablets
Culturelle® Kids Purely Probiotics Packets
L. rhamnosus GG
AAD - Antibiotic associated diarrhea - Prevention
(I)
CE/AD - Childhood eczema/ Atopic dermatitis
(I)
CID - Common infectious disease - community acquired
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
LH - Liver Health (NASH/NAFLD/MHE; as adjunct to standard therapy; see studies for specific population) (II)
NI - Nosocomial infections prevention - hospital acquired
(I)
Powder
5B/packet
1-2 packets
Culturelle® Probiotics Baby Digestive Calm+Comfort
🌾
L. rhamnosus GG
B. lactis BB-12
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired (II)
Drops
2B/5 drops
5 drops
Culturelle® Probiotics Baby Healthy Development
🌾
(with Vitamin D 400IU)
L. rhamnosus GG
B. lactis BB-12
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired (II)
Powder
3.5B/packet
1 packet
Culturelle® Probiotics Baby Immune+Digestive Support
🌾
(with Vitamin D 400IU)
L. rhamnosus GG
B. lactis BB-12
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired (II)
Drops
2.5B/5 drops
5 drops
DanActive
Actimel®
🍀
❄
L. casei sp. paracasei CNCM I-1518
CID - Common infectious disease - community acquired
(I)
HP - Helicobacter pylori - Adjunct to standard eradication therapy
(I)
ID - Infectious diarrhea (II)
Ferm. milk lq.
10B/serving
1-2 servings
Floradapt Baby Colic
🌾
B. longum CECT7894/KABP042®
P. pentosaceus CECT8330/KABP041®
Colic - Colic
(I)
Drops
1B/5 drops
5 drops
FlorastorKids®
🌾
Saccharomyces boulardii lyo CNCM I-745
AAD - Antibiotic associated diarrhea - Prevention
(I)
CDAD - Clostridium difficile associated diarrhea - Prevention (III)
HP - Helicobacter pylori - Adjunct to standard eradication therapy
(I)
ID - Infectious diarrhea
(I)
Sachet
Capsule
5B/sachet
5B/capsule
1-2 sachets
1-2 capsules
Gerber® DHA & Probiotic Rice Cereal
Gerber® Cereal for Baby
Gerber® Power Blend™ Cereal
🍀
B. lactis BB-12
AAD - Antibiotic associated diarrhea - Prevention
(I)
CID - Common infectious disease - community acquired
(I)
Cereal
1B/serving [serving =1/4 cup]
1 serving
Gerber® Good Start® GentlePro Powder Infant Formula
🍀
B. lactis BB-12
CID - Common infectious disease - community acquired
(I)
Powder
1M/gram
Routine feeding if alternative to breast milk is required
Gerber® Good Start® Grow Toddler Drink
🍀
B. lactis BB-12
AAD - Antibiotic associated diarrhea - Prevention
(I)
CID - Common infectious disease - community acquired
(I)
Powder
1B/200mL serving
1 serving
Gerber® Good Start® Soothe Comforting Probiotic Drops
🌾
L. reuteri DSM 17938
AAD - Antibiotic associated diarrhea - Prevention
(I)
C - Constipation
(I)
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired
(I)
Colic - Colic
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
NEC* - Necrotizing Enterocolitis (newborn) *as per hospital protocol, not for self-administration
(I)
Regurg/ GI Mot - Reduces regurgitation/ Improves gastrointestinal motility
(I)
Drops
100M/5 drops
5 drops
Gerber® Good Start® Soothe Vitamin D & Probiotic Drops
🌾
L. reuteri DSM 17938
AAD - Antibiotic associated diarrhea - Prevention
(I)
C - Constipation
(I)
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired
(I)
Colic - Colic
(I)
IBS/FAP - Irritable bowel syndrome/Functional abdominal pain
(I)
ID - Infectious diarrhea
(I)
Regurg/ GI Mot - Reduces regurgitation/ Improves gastrointestinal motility
(I)
Drops
100M/5 drops
5 drops
Gerber® Good Start® SoothePro Powder Infant Formula
🍀
L. reuteri DSM 17938
ID - Infectious diarrhea
(I)
Powder
1M/gram
Routine feeding if an alternative to breast milk is required
HMF Fit for School
🌾
[50 mg vitamin C, 1000IU vitamin D]
L. acidophilus CUL-60
L. acidophilus CUL-21
B. animalis subsp. lactis CUL-34
B. bifidum CUL-20
CID - Common infectious disease - community acquired
(I)
Chewable tablet
Powder
12.5B/tablet
12.5B/scoop
1 tablet
1 scoop
MetaKids™ Baby Probiotic
🌾
L. rhamnosus GG
B. lactis BB-12
CE/AD - Childhood eczema/ Atopic dermatitis (II)
CID - Common infectious disease - community acquired (II)
Drops
1B/6 drops
6 drops
MetaKids™ Probiotic
🌾
L. acidophilus NCFM®
B. animalis subsp lactis Bi-07®
CID - Common infectious disease - community acquired
(I)
Chewable tablet
5B/tablet
2 tablets
Mommy's Bliss Colic Support
🌾
B. longum CECT7894
P. pentosaceus CECT8330
Colic - Colic
(I)
Drops
1B/5 drops
5 drops
Neocate® Syneo® Infant
🍀
Amino acid-based formula (AAF)
B. breve M-16V
CMPA - Cow Milk Protein Allergy (including Colic due to CMPA) (II)
Powder
1.4 x 10⁹ CFU per 100 mL serving
AAF when an alternative to breast milk is required
Nestle NAN Pro Toddler Drink
🍀
L. reuteri DSM 17938
AAD - Antibiotic associated diarrhea - Prevention
(I)
ID - Infectious diarrhea
(I)
Powder
1B/200mL serving
1 serving
Nestle’ Health Science Extensive HA® Hypoallergenic Infant Formula
🍀
Extensively hydrolyzed whey formula (EHWF)
B. lactis BB-12
CID - Common infectious disease - community acquired
(I)
Powder
1M/gram
EHWF when an alternative to breast milk is required
Nutramigen® with Enflora™LGG®
🍀
Extensively hydrolyzed casein formula (EHCF)
L. rhamnosus GG
[Branded LGG]
CMPA - Cow Milk Protein Allergy (including Colic due to CMPA)
(I)
Powder
1.35 x 10⁷ CFU per 100 mL serving
EHCF when an alternative to breast milk is required
OMNi-BiOTiC® PandA
🌾
Lactococcus lactis W58
B. lactis W52
B. lactose W51
B. bifidum W23
CE/AD - Childhood eczema/ Atopic dermatitis (II)
Sachet
3B/sachet
1 serving
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❄
- Product requires refrigeration
🍁
- Approved by Health Canada for listed application; applicable to supplements
🍀
- Functional Foods
🌾
- Gluten Free
DISCLAIMER
The statements made regarding products listed here have not been evaluated by the Food and Drug Administration or Health Canada (unless otherwise indicated). Information in this guide is not intended to diagnose, treat, cure, or prevent any disease. Products, services, information and other content provided on this Site, including information that may be provided on this Site directly or by linking to third-party websites are provided for informational purposes only. Please consult with a physician or other healthcare professional regarding any medical or health-related questions. Manufacturer indications for use can be found on product labels. This chart is reflective of published evidence available to date. It does not represent an endorsement of any specific product. Work on this guide is done independently and without financial conflict. In order to minimize bias, publishing and distribution efforts are coordinated via Alliance for Education on Probiotics (AEProbio). We are grateful for unrestricted publishing grant AEProbio is providing for continuous efforts to translate science into clinically applicable form.
2024 Version, last modified January 2024, valid until Dec. 31, 2024. © BHSoftInc
Please forward any questions or comments to the author Dragana Skokovic-Sunjic (dsunjic@bhsoftinc.com)